Biological monitoring in surveillance of exposure to genotoxicants. It is believed that ethylene is not produced in species outside the plant kingdom and some microorganisms. The MAK‐Collection for Occupational Health and Safety. Tubes with residues of 200 to 600 ppm ethylene oxide brought about a consistent rise of the SCE ratio in the sense of a dose-response relationship. Fruit Ripening 2. October 1, 2020 By Nancy Crotti. Learn about our remote access options, Section of Health Risk Assessment, Minnesota Department of Health, Minneapolis, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Department of Surgery, Hennepin County Hospital, Minneapolis. 1, 3-butadiene, ethylene oxide and vinyl halides (vinyl fluoride, vinyl chloride and vinyl bromide). Ethylene Oxide. The dangerous side effects and human carcinogen health risks involved in the use of Ethylene Oxide have mostly been hidden from public view. Ethylene oxide (EtO) is produced in large volumes and is primarily used as an intermediate in the production of several industrial chemicals, the most notable of which is ethylene glycol. and you may need to create a new Wiley Online Library account. Profile for ethylene oxide, Toxicological Human diploid VH-10 fibroblasts were pre-exposed to γ-rays and then treated with ethylene oxide (EtO). Garry VF, Hozier J, Jacobs D, Wade RL, Gray DG. Effect of concentration—time parameters on sister-chromatid exchanges induced in rabbit lymphocytes by ethylene oxide inhalation. It dissolves easily in water.Ethylene oxide is a man-made chemical that is used primarily to make ethylene glycol (a chemical used to make antifreeze and polyester). Note: Javascript is disabled or is not supported by your browser. To determine the minimum sterilization time required and the effect of ethylene oxide on bone's osteoinductive capacity and chemical structure, samples were exposed to ethylene oxide for different times (5-240 min). The genotoxic effects of three important aliphatic epoxides, ethylene oxide (EtO), propylene oxide (PO) and the halogenated epoxide epichlorohydrin (ECH), are described. Genetic Toxicology of Some Known or Suspected Human Carcinogens. Headache, nausea, and vomiting have been reported. The major effects seen in workers exposed to ethylene oxide at low levels for several months or years are irritation of the eyes, skin, and mucous membranes and problems in the functioning of the brain and nerves. Draft Toxicological Profile for Chlorine Dioxide and Chlorite. Neurotoxicological evaluation of hospital sterilizer workers exposed to ethylene oxide. Ethylene Oxide, Mustard Gas and other organics, and to accelerate the ripening of fruits. To study the problem in a hospital sterilization facility where occupational exposure was suspected, epidemiologic, analytic, and bioassay tools were employed. Garry VF, Hozier J, Jacobs D, Wade RL, Gray DG. Ethylenoxid [MAK Value Documentation in German language, 2002]. EPA has concluded that ethylene oxide is carcinogenic to humans by the inhalation route of exposure. Authors. Ethylene oxide causes acute poisoning, accompanied by the following symptoms: slight heartbeat, muscle twitching, flushing, headache, diminished hearing, acidosis, vomiting, dizziness, transient loss of consciousness and a sweet taste in the mouth. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use. Review of the mutagenicity of ethylene oxide. Ethylene oxide gas may produce immediate local irritation of the skin, eyes, and upper respiratory tract. The incidence of Achilles's tendon reflection, knee jerk slacking up, chronic pharyngitis, coryza, acne, hair lose and pneumonia were significantly higher in study group than that in control group (P <0.01). In 2016, the EPA classified ethylene oxide as cancerous to humans. Two different dose rates of γ-rays were used: a low dose rate (LDR, 0.66 Gy/min) and a high dose rate (HDR, 10 Gy/min). Among male Fischer 344 rats in the same experiment EtO induced peritoneal mesothelioma which originated in the testicular mesothelium. The NTP brief is intended to provide clear, balanced, scientifically sound information on the potential for ethylene glycol exposures to result in adverse effects on human Provides exposure risks, exposure limits, and health effects for ethylene oxide. 2005; 23(1):6-8 (ISSN: 1001-9391) Sun LL; Zhang FQ . [Effects of ethylene oxide and propylene oxide on human health]. Chromosomal aberrations and micronuclei in lymphocytes in relation to alkylation of hemoglobin in workers exposed to ethylene oxide and propylene oxide. It is also used as a fumigant in certain agricultural products and as a sterilant for medical equipment and supplies. An Evaluation of Possible Effects on Health Following Exposure To Ethylene Oxide. Inhalation of ethylene oxide can produce CNS depression, and in extreme cases, respiratory distress and coma. Ethylene Oxide 75-21-8 Hazard Summary The major use for ethylene oxide is as a chemical intermediate in industry. Ethylene oxide causes acute poisoning, accompanied by a variety of symptoms. ToxFAQs™ for Ethylene Oxide. Mutagenicity testing in environmental toxicology. Another group of eight persons with fewer complaints studied as late as the ninth week showed significantly increased exchanges. An Overview of Approaches for Genetic Monitoring of Humans. 1.7 What recommendations has the federal government made to protect human health? The following points highlight the eleven major physiological effects of ethylene. Evaluation in Man and Animals of Tests for the Detection of Population Exposures to Genotoxic Chemicals. SCE increases after an accidental acute inhalation exposure to EtO and recovery to normal after 2 years. Ethylene Oxide and Some Factors Affecting the Mutagen Sensitivity of Sister Chromatid Exchange in Humans. Chronic ethylene oxide exposure may increase the risk of cataracts in humans. Statistical model for prediction of retrospective exposure to ethylene oxide in an occupational mortality study. Many other chemical substances have mutagenic potencies also. Residues in medical equipment that has been sterilized with ethylene oxide and insufficiently aerated can migrate into tissues and blood, producing primarily local effects. 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